acushdogsmom
11-28-2002, 06:05 AM
Hi all,
A friend of mine just sent me this information.
The Royal Vet College in the UK is apparently going to be doing a new "Trial" to test the efficacy of Trilostane when used twice daily (the current dosing protocol is once daily).
If I understand correctly, this new trial is being done because action of Trilostane, ie. it's inhibition of cortisol synthesis, is quite short-lived, which is why it must be given every day to be effective, and they want to see if it might be more beneficial to give doses twice a day rather than only once a day.
This short-lived effect of Trilostane is actually one of the promoted benefits of the drug since its effect can be reversed by simply stopping the drug, but because of the short-lived effect of Trilostane it may be that the cortisol levels of a dog who is on Trilostane might be higher later in the day than they would be, say, four hours after having received the daily dose for example, and so the cortisol levels may not actually be at consistently low levels for each 24 hour period and consistent cortisol levels would be better.
Trilostane has already been proven to be effective in trials done at the Royal Vet College before it was approved in the UK as a Canine Cushing's treatment (in Oct/Nov 2001) but it is better for a Cushing's dog to have cortisol levels kept lowered right through every 24 hour period, and so giving it twice a day might be better than only once a day if cortisol levels are actually rising somewhat as it "wears off" at some point before the next once daily dose is given.
Anyhow, that's how I understood what I recently heard about the reason for the new trials they are doing
I have a link to the website where you can read the announcement by the Royal Vet College about this new Trilostane trial they will be doing:
www.rvc.ac.uk/Hospitals/Q...m#cushings (http://www.rvc.ac.uk/Hospitals/QMH/Clinical_Trials/Medicine.cfm#cushings)
Since I don't know how long this link will be valid here is what it says as of this date (November 28/02):
-----------------------------------------------------
Cushing's disease—NEW Trilostane trial
Recent studies at the RVC have shown that trilostane, a competitive inhibitor of 3E-hydroxysteriod isomerase is an effective treatment for hyperadrenocorticism in dogs, when administered once daily.
We are about to embark on a new study to determine the efficacy of twice daily dosing.
Dogs that have been diagnosed with hyperadrenocorticism but have not yet received treatment or dogs that have previously been treated but have not received medication in the last 3 months may be eligible for the study.
All consultations, blood tests or other diagnostic tests required by the study will be provided free of charge to the owner. Dogs recruited to the study will be monitored over a 24 week period, trilostane will be supplied free of charge during this time. If you would like any further information or have a dog with hyperadrenocorticism that you would like to refer for the study, please contact Dr Reto Neiger on (01707) 666365
A friend of mine just sent me this information.
The Royal Vet College in the UK is apparently going to be doing a new "Trial" to test the efficacy of Trilostane when used twice daily (the current dosing protocol is once daily).
If I understand correctly, this new trial is being done because action of Trilostane, ie. it's inhibition of cortisol synthesis, is quite short-lived, which is why it must be given every day to be effective, and they want to see if it might be more beneficial to give doses twice a day rather than only once a day.
This short-lived effect of Trilostane is actually one of the promoted benefits of the drug since its effect can be reversed by simply stopping the drug, but because of the short-lived effect of Trilostane it may be that the cortisol levels of a dog who is on Trilostane might be higher later in the day than they would be, say, four hours after having received the daily dose for example, and so the cortisol levels may not actually be at consistently low levels for each 24 hour period and consistent cortisol levels would be better.
Trilostane has already been proven to be effective in trials done at the Royal Vet College before it was approved in the UK as a Canine Cushing's treatment (in Oct/Nov 2001) but it is better for a Cushing's dog to have cortisol levels kept lowered right through every 24 hour period, and so giving it twice a day might be better than only once a day if cortisol levels are actually rising somewhat as it "wears off" at some point before the next once daily dose is given.
Anyhow, that's how I understood what I recently heard about the reason for the new trials they are doing
I have a link to the website where you can read the announcement by the Royal Vet College about this new Trilostane trial they will be doing:
www.rvc.ac.uk/Hospitals/Q...m#cushings (http://www.rvc.ac.uk/Hospitals/QMH/Clinical_Trials/Medicine.cfm#cushings)
Since I don't know how long this link will be valid here is what it says as of this date (November 28/02):
-----------------------------------------------------
Cushing's disease—NEW Trilostane trial
Recent studies at the RVC have shown that trilostane, a competitive inhibitor of 3E-hydroxysteriod isomerase is an effective treatment for hyperadrenocorticism in dogs, when administered once daily.
We are about to embark on a new study to determine the efficacy of twice daily dosing.
Dogs that have been diagnosed with hyperadrenocorticism but have not yet received treatment or dogs that have previously been treated but have not received medication in the last 3 months may be eligible for the study.
All consultations, blood tests or other diagnostic tests required by the study will be provided free of charge to the owner. Dogs recruited to the study will be monitored over a 24 week period, trilostane will be supplied free of charge during this time. If you would like any further information or have a dog with hyperadrenocorticism that you would like to refer for the study, please contact Dr Reto Neiger on (01707) 666365